Development of novel biophysical/biochemical techniques at the nanoscale

We are developing novel techniques that can make new types of biophysical/biochemical measurements on molecular interactions at the single-molecule level, combining nano/microfabrication, microfluidics, and quantitative fluorescence imaging.


  • Mass action at the single-molecule level
    Min Ju Shon & Adam E. Cohen
    J. Am. Chem. Soc. 134, 14618–14623 (2012)
  • Nano-mechanical measurements of protein-DNA interactions with a silicon nitride pulley
    Min Ju Shon & Adam E. Cohen
    Nucleic Acids Res. 44, e7 (2016)

  • Profiling protein–protein interactions of single cancer cells with in situ lysis and co-immunoprecipitation
    Ji Young Ryu*, Jihye Kim*, Min Ju Shon*, Jiashu Sun, Xingyu Jiang, Wonhee Lee & Tae-Young Yoon
    Lab Chip 19, 1922–1928 (2019)

  • Profiling of protein–protein interactions via single-molecule techniques predicts the dependence of cancers on growth-factor receptors
    Hong-Won Lee et al.
    Nat. Biomed. Eng. 2, 239–253 (2018)

  • Observing extremely weak protein-protein interactions with conventional single-molecule fluorescence microscopy
    Janghyun Yoo, Tae-Sun Lee, Byungsan Choi, Min Ju Shon & Tae-Young Yoon
    J. Am. Chem. Soc. 138, 14238–14241 (2016)